IBSyncrasy

by Theodoros Prevedoros

49,00 € – 69,00 €

IBSyncrasy

by Theodoros Prevedoros

noun: idiosyncrasy /ˌɪdɪə(ʊ)ˈsɪŋkrəsi/

a distinctive feature or characteristic of a place or thing or person…

Every human is unique…. every action, movement and thought is processed and executed in his own idiosyncratic way. The same applies to human pathologic states like Irritable Bowel Syndrome. Every human responds differently to the same symptom, to the same underlying cause and to the same trigger, whether it is a food reaction or a minor surgery. Therefore, as unique are someone’s healthy characteristics, the same applies to his disease symptoms. And when it comes to IBS, every one exhibits their one idiosyncrasy…. their IBSyncrasy

49,00 € – 69,00 €

Book Type

Clear

Pages:

308

Book format:

PDF

Publication date:

07/12/2021

The concept

same symptoms, UNIQUE

Demographics

Biochemistry

Lifestyle

Medical history

Genetics

IBS IS NOT ONE DISEASE – IT IS NOT EVEN SOME DISEASES

It is a spectrum of different symptoms stemming from each patient’s individuality. By mining all the biochemical data of a patient, a unique treatment is revealed, according to their IBSyncrasy

Discover

How digestion works in real life (and not in textbooks)
Why “not” eating is equally important to eating
How your gut is interconnected with all your organs
Why you should treat your gut like an organ that resides outside your body, like your skin (Hint: it does)
Food is not the problem, merely the messenger of the symptom
How time is imprinted within our genome and dictates digestion

How to identify your IBSyncrasy
What you have in common with other patients (and what to do about it)
Which are the correct exams that will reveal your own pathology
The exact treatment for your case
Which additional therapeutic modules will accelerate your healing
What to do to remain healthy after the treatment

Contents

SECTION A

Chapter 01

From advanced biochemistry to 4,500 medical histories

Human homeostasis is not something that can be described in a textbook. It cannot even be defined properly because parts of its definition are still not known. It is the sum of all the trial-and-error procedures happening in the human ecosystem, and all the ecosystems before humans, that led to the concept of human life. So, trying to heal a disordered homeostasis by giving a supplement or a drug is not an option, or at least not a viable one. Supplements and drugs are tools. Tools that work only when used properly and timely. The very first prerequisite for healing and curing a diseased state is the adherence to our evolutionary standards and respect to all the components that make us what we are; a multi-system symbiotic multi-cellular machinery with the highest degree of sophistication known so far.

And when it comes to the gastrointestinal tube things get a lot more complicated. Because besides human biochemistry, an additional amount of 100.000.000.000 biochemistries are added with thousands of different genomes interacting with each other and with the host.

Biochemistry expands diagnostic accuracy

How can so many different molecular alterations only produce the generally accepted 800 symptoms that exist? It is easily understandable that there are plenty of different combinations that may bring the same disease or the same symptom to the surface.

Let us take nausea as an example. Nausea is just a symptom; it may be a symptom of Meniere’s disease, or a symptom of a labyrinth problem, or it may appear in the context of gastroesophageal reflux disease or even from hemorrhoids bleeding. Nausea may be a symptom in the context of hundreds of diseases, and each and every one of these diseases may be the result of thousands of different biochemical malfunctions. So just by treating nausea, it does not mean that you repair the biochemical anomalies that induced it in the first place, and, of course, every single patient suffering from nausea needs different management. That is where clinical biochemistry comes into the picture. All the data that can be extracted in a 2-hour session, combined with the patient’s symptomatology, help us isolate specific biochemical systems for further diagnostic checking.

How simple techniques make the patient more adherent

While most think that a doctor should be highly trained in medicine and only in medicine, in my opinion storytelling should also be part of their education. The ability of a doctor to persuade the patient to change his daily routine to get well is of the utmost importance. This is because a large proportion of patients rely solely on taking a medication or the result of an operation.

Reasons why a treatment may fail that has nothing to do with the treatment scheme:

The patient stops the treatment prematurely
The patient changes the dosage at will
The patient read something on the internet
The patient is seeing more than one doctor at the same time
The patient cannot get in touch with his/her doctor
The doctor does not inspire confidence
The doctor is not answering the patient’s questions
The timing of the treatment is not correct
The doctor rejects symptoms that he/she is not familiar with
The doctor is unwilling to give lifestyle and dietary advice, despite the patient asks for it

Chapter 02

Stress as an aggravating factor – not the cause

When the patient is asked all the triggering factors of their symptoms, stress and anxiety are always present. In most cases, acute stressful situations induce diarrhea or bloating, whereas more chronic anxious states induce constipation. The opposite may be also true. As a result, patients think that stress is the primary cause of their IBS and that if they resolve it, IBS will disappear. Unfortunately, many physicians tend to accentuate this notion by telling their patients the typical phrase: Don’t worry, there’s nothing wrong with your gut, it’s all in your head!

Why do most irritable bowel patients associate stress with symptom exaggeration?

The answer lies in the role stress plays in the evolution of the human species. And it is well explained. To cut a long story short stress is an exaggerating factor for IBS symptoms and not the root cause of IBS pathology.

Chapter 03

Biochemistry data mining – The tools

During my 15 years of practice I have tried many therapeutic modules which involve all aspects of everyday life besides, of course, pharmaceuticals and nutraceuticals. These aspects involve dietetic, nutritional, lifestyle and psychological interventions. Many proved to be of no help, either because they were too hard to implement, or they just did not work. Some of them, though, proved to be very useful – if practiced correctly, they are not just an add-on to the treatment, but an invaluable part of the healing process. The module-pyramid depicts the importance of each layer and the magnitude of contribution to the treatment.

Your gut has its own stopwatch

Some call it time-restricted feeding, others intermittent fasting (IF). Well, I call it common sense. It is the process of eating, and not the food itself, that is destroying your gut – … when digestion finishes, another energy-consuming period begins, the post digestive one. Now that all the debris, killed bacteria, bile, and food particles have accumulated in the small intestine, they have to be eliminated. This process is also very important in evolutionary terms, since it is regulated by the brainstem itself; the base of the brain. Even 4-6 hours after the previous meal, rigorous and repeated movements must be allowed to happen in order to forward every single piece of debris to the colon for stool formation to take place.

Time is imprinted in our genes

The 24hr light-darkness cycle is not just an external environmental phenomenon, but a crucial regulator of almost every biochemical reaction humans possess. Besides the three structural dimensions (height, width, depth), time is also an integral part of our physiology. However, unlike the others, the dimension of time is invisible and thus hard to comprehend. This 4th dimension is deeply imprinted inside our genome and in the last 20 years more and more functions of these “clock” genes are being uncovered. Disrupting our circadian clock predisposes us for many chronic diseases. It is no wonder that night shift workers are more prone to almost all chronic diagnoses.

Different tests tell different stories

The most common phrase I hear in my office from patients in our first meeting is “I have done every test possible” and, indeed, in terms of mainstream practice, all the tests have been done – tests to exclude cancer, to exclude Crohn’s disease or ulcerative colitis, to exclude H. pylori infection or celiac disease and any number of other inflammatory and malignant disorders. However, IBS is a functional disorder. It is a set of symptoms giving rise to an individual phenotype. So, what is the use of these tests and procedures besides excluding more serious diseases? In the classic view of IBS, none, because these tests are used to exclude and not diagnose, and as with every other organ in our body the best way to find out what is going on with the bowels is by searching in their own product. Stools are the carrier of gut pathogenicity and the best way to find out what is going on is to use them as diagnostic sample. In addition, several blood and urine tests are helpful for the final diagnosis.

Your gut is vegetarian

It may sound counterintuitive to fiber up, as dietary fiber is the most common cause of abdominal distension and IBS exaggeration. But if sone the right way, it is the only option for long-term symptoms relief.

Up to 99% of the total intestinal microbial load resides in the last part of our gut, the large colon. This approximately 1.5-meter-long tube is covered, in its luminal face, with several millimeters of mucus which is where most of the bacteria live. The mucosal lining is characterized by different physicochemical properties depending on the part of the intestine in which it resides. These different microenvironments are decisive for the kind and the number of bacteria it hosts. What is important is that the colonic environment is an anaerobic one and, thus, the reactions that feed our microbiome and help them produce vitamins and postbiotics will as well be anaerobic. This is the reason why plant fiber (anaerobic fuel) is their food of choice.

They just don’t work

Almost every patient I have consulted has already tried at least one brand of probiotics; either prescribed by a practitioner or suggested by a friend. Usually, patients report that they did notice some benefit, although symptoms persisted. Others do not see any improvement, while some of them report that they actually got worse. It is natural for probiotics to give such diverse results because there is no guarantee that a random probiotic is what you need or even if it is the right one. There is no way to know whether the specific strain, in the specific amount, taken in combination with other competitive strains will eventually colonize in the correct gut segment. The probability of healing while just taking a random probiotic is the same as winning the lottery… twice. By healing we are not talking about a statistical improvement in a symptom or two; we mean full symptom resolution, for good.

A few factors determining the kind of probiotic needed:

Diet
Previous medical treatments
Geographic location
Bowel habits
Systemic diseases
Mode of delivery
… many many more

SECTION B - Case Studies

Case Study 1

Post Infectious IBS

When that gastroenteritis seems to last forever

It is perhaps the most common trigger of irritable bowel symptoms. When the intestinal environment is already vulnerable, a powerful infectious agent can cause significant changes in both the mucosa and the flora

Case Study 2

Post Cholecystectomy IBS

The alkaline disaster

IBS patients who presented with symptoms after gallbladder removal or their symptoms exaggerated after the surgery. IBS may manifest directly after the surgery until 7 years later

Case Study 3

Proteus-predominant IBS

Glutamine is not always an ally

IBS patients whose MS-microbiology tests reveal massive colonization by Proteus spc. Commonly after antibiotic treatment

Case Study 4

Pseudomonas-predominant IBS

It feels like celiac disease, but it's not

IBS patients whose MS-microbiology tests reveal massive colonization by Pseudomonas spc. Commonly pet owners and people with gluten sensitivity

Case Study 5

IBS and prostatitis

A vicious antibiotic cycle

IBS patients presenting with chronic prostatitis or pelvic pain. Most commonly prostatitis appears first but the opposite is also true

Case Study 6

Pancreatic insufficiency and IBS

The metabolic face of IBS

IBS is another manifestation of systemic diseases like diabetes, pancreatitis, and fatty liver disease

Case Study 7

PPI's abuse

Bowel problems go through the stomach

IBS patients who have used proton pump inhibitors for more than 6 months in total. Other substances have similar effect

Case Study 8

sIgA deficiency

My mama's antibodies are better than yours

Mucosal immunity compromized individuals exhibit gut symptoms more frequently. Commorbidities may include frequent low grade fever, fatigue and atopic diseases

Case Study 9

SIBO - Dysfunctional vagal nerve

Eating whenever you want is NOT your choice

People whose gut housecleaning-mechanism are not working properly and present with SIBO and vagus nerve imbalances

Case Study 10

Pediatric IBS

C-section/Lack of breasteeding/Early antibiotics

C-section/Minimal breastfeeding/Early antibiotics. Even one of these is enough to pave the way for bowel symptoms in infancy and childhood

Structure

Whom this case concerns
What do people suffering from this kind of IBS have in common
Age, gender and ethnicity affected mostly by this IBSyncrasy

Analytic and comprehensive presentation of this IBSyncrasy
Which are the common risk factors. Maybe you will find yours
How it differs form other IBSyncrasies

Common medical, dietary and behavioral history of this IBSyncrasy
All therapies and diets that failed in the first place
The diagnostically useful data of this IBSyncrasy and the ones that don’t matter
The importance of storytelling

Which diagnostics were chosen and on what basis
How symptoms and triggers translate to specific tests
Why most of the patients’ past exams were diagnostically useless

Every result explained in simple terms
How the results relate to patient’s IBSyncrasy
Tha exact mechanism of each finding’s pathogenicity

Every treatment aspect explained in simple terms (medicines, supplements, nutrition, behavioral interventions etc.)
How treatment changes according to every patient’s IBSyncrasy
What are the determining factors that will make you adhere to the treatment all the way

How to identify deviations from the treatment and correct them in real-time
How long each IBSyncrasy takes to heal
Why every individual’s findings and history define the outcome and the duration of treatment

Why this IBSyncrasy could not be treated as a disease but as an individual IBSyncrasy
How Biochemistry helped to identify the real culprits behind this case

Whom this case concerns
What do people suffering from this kind of IBS have in common
Age, gender and ethnicity affected mostly by this IBSyncrasy

Analytic and comprehensive presentation of this IBSyncrasy
Which are the common risk factors. Maybe you will find yours
How it differs form other IBSyncrasies

Common medical, dietary and behavioral history of this IBSyncrasy
All therapies and diets that failed in the first place
The diagnostically useful data of this IBSyncrasy and the ones that don’t matter
The importance of storytelling

Which diagnostics were chosen and on what basis
How symptoms and triggers translate to specific tests
Why most of the patients’ past exams were diagnostically useless

Every result explained in simple terms
How the results relate to patient’s IBSyncrasy
Tha exact mechanism of each finding’s pathogenicity

Every treatment aspect explained in simple terms (medicines, supplements, nutrition, behavioral interventions etc.)
How treatment changes according to every patient’s IBSyncrasy
What are the determining factors that will make you adhere to the treatment all the way

How to identify deviations from the treatment and correct them in real-time
How long each IBSyncrasy takes to heal
Why every individual’s findings and history define the outcome and the duration of treatment

Why this IBSyncrasy could not be treated as a disease but as an individual IBSyncrasy
How Biochemistry helped to identify the real culprits behind this case

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