Gastroenterology

The chaotic nature of the gastrointestinal system makes it a perfect candidate for Biochemistry Data Mining application. Every proximal or distal system may ultimately produce the same gut symptoms.

Commonly overlooked gut pathology parameters​
Gastroenterology
Neurogastroenterology
The intestinal tube is the largest surface to be controlled by neurons. In fact, vagus nerve, the largest in our body, controls much of the function of the stomach, the small and the large intestine, and is critical in syndromes like IBS
Gastroenterology
bile biochemistry
Bile is a highly essential substance, needed for the emulsification and absorption of lipids. However, it acts also as a hormone, neurotransmitter and cancer mediator.
Gastroenterology
postbiotic metabolism
Postbiotics are all the necessary products derived from bacterial or fungal metabolism that humans cannot synthesize. For example, butyrate, which I believe serves superior functions from all the other vitamins, is a product of fiber fermentation
Gastroenterology
immunogastroenterology
Mucosal immunity is the interface between what happens outside our body and inside it. It is the last frontier and when compromised, our body is subject to every external threat. Secretory immunoglobulin A, bacterial derived defensins, mucins, adhesion proteins and other molecules are implicated in gastrointestinal pathology​
Gastroenterology
hormonal imbalances
Visceral hypersensitivity, estrogen and progesterone control, thyroid regulation and in fact almost all hormones in our body have the potential to alter bowel function leading to symptoms like constipation, residual feeling, urgency etc​
Gastroenterology
microbiome
It is now accepted to be an endocrine organ. It possesses 10 times more genes than we do and depending on the circumstances they became either friends, or foes​
Other Applications
Autoimmunity
Innate, adaptive passive and humoral…. All kinds of molecules and cells interact to form the most complex system in nature. Even two identical immune responses may give different disease phenotypes
OH N H O
Pediatrics
Infants, toddlers and teenagers have distinct metabolic features making their biochemistry unique in every way. Constant hormone fluctuations and evolving developmental stages should always be taken into account
Rare
Nausea, fatigue, migrating pain, symptoms that fluctuate according to the time of the day. All sorts of peculiar symptoms originate from a disorganized biochemical system
Neurodevelopment
From conception until puberty there are constant dynamic interactions happening between our central nervous system and the environment, building and remodeling our perception of the world